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A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients

RecruitingNAAges 18 Years - 75 YearsAllUniversity of Greifswald
NCT04996433 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x) * Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20 * Treatment-resistance (TR) (defined by the ATHF-SF or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current episode) * Sufficient knowledge of the German language * Written informed consent Exclusion Criteria: * Bipolar I or II disorder * Active substance use disorders (abstinence shorter than 6 months) * Schizophrenia spectrum and other psychotic disorders * Antisocial personality disorder * Acute suicidality (HRSD item 3 \> 2 or agreement with C-SSRS item 4 and/or item 5) * Previous CBASP or BA treatment within the last year * Inability to tolerate CBASP or BA (e.g., organic brain disorders, severe cognitive deficits) * Inability to participate in dayclinic or outpatient continuation treatment * Participation in another (psycho)therapeutic study of an interventional nature
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What it tests

  • inpatient CBASP individual therapy
  • inpatient CBASP group therapy
  • inpatient CBASP nurse contact
  • inpatient CBASP exercise therapy
  • outpatient CBASP group therapy
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Where

8 sites
Charité, University Medicine Berlin
Berlin, Germany
Universitätsklinikum Bonn
Bonn, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitätsklinikum Jena
Jena, Germany
Universität zu Lübeck
Lübeck, Germany
Universitätsklinikum Marburg
Marburg, Germany
Klinikum der Universität München
München, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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