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Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

RecruitingNAAges 18 Years - anyAllUniversity of Pittsburgh
NCT04996628 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain. * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL). * Surgery: drainage procedures (Frey and Puestow operations) Exclusion Criteria: * Patients with chronic pain from conditions other than CP * Patients \< 18 years of age * Patients who have had endoscopic therapy within the past 12 months * Patients who have undergone prior pancreatic surgery * Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy) * Patients with peripheral sensory deficits * Patients with known pregnancy at the time of study screening\*\* * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.
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What it tests

  • Quantitative Sensory Test 1
  • Quantitative Sensory Test 2
  • Quantitative Sensory Test 3
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Where

3 sites
Indiana University Medical Center
Indianapolis, United States
Johns Hopkins Medical Institutions
Baltimore, United States
University of Pittsburgh Medical Center
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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