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Artificial Intelligence Guided Patient Selection for Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial (AI-PAFA Trial)

RecruitingNAAges any - anyAllYonsei University
NCT04997824 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atrial fibrillation (AF) is a major cardiovascular disease with a prevalence of 1.7% of the total population in Korea, associated with 25% of ischemic stroke and 30% of heart failure, and is a major cardiovascular disease that doubles the risk of dementia. AF catheter ablation (AFCA) is an effective procedure that lowers the risk of heart failure mortality and cerebral infarction and improves cognitive or renal functions. However, the recurrence rate after the procedure is relatively high, especially in patients with long-standing persistent AF in which atrial remodeling has already progressed. Research on the prediction of treatment efficacy using artificial intelligence (AI) is being actively conducted around the world. We predicted the AFCA poor responders who will progress to permanent AF despite AFCA among a total of 3,372 patients included in the Yonsei AF Ablation cohort and the 2

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Left atrium size \< 55 mm 2. AF recurred during the administration of antiarrhythmic drugs or that antiarrhythmic drugs intolerable patients 3. Patients eligible for anticoagulant therapy (to prevent thromboembolic events) Exclusion Criteria: 1. AF associated with severe cardiac anomalies or structural heart disease with hemodynamic influence 2. Patients who have difficulty in CT imaging using a contrast medium 3. Patients with active internal bleeding 4. Inappropriate anticoagulant therapy 5. Serious comorbidities 6. Patients expected to survive less than 1 year 7. People with drug or alcohol addiction 8. Those who cannot read the consent form (illiterate, foreigners, etc.) 9. Patients who are judged unsuitable for participation in clinical research by the judgment of other investigators
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What it tests

  • Artificial Intelligence-based atrial fibrillation catheter ablation
  • Medical Therapy
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Where

1 site
Severance Hospital, Yonsei University Health System
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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