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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Recruitingn/aAges 8 Years - 14 YearsAllPetter Bjornstad
NCT05008276 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.

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📋 Eligibility rules (as published)
Inclusion Criteria: * HbA1c ≥6.0% for untreated high-risk group * BMI ≥ 85th %ile for high-risk group * Normal HbA1c ≤5.6% for control group * Type 1 diabetes (T1D) Antibody negative Exclusion Criteria: * History of Chronic kidney disease (CKD) or acute kidney injury (AKI) * Metabolic disorder prohibiting safe fasting * Iodine or penicillin allergy * Pregnancy * Thrombophilia * MRI contraindications * Hormone therapy
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What it tests

  • Aminohippurate Sodium Inj 20%
  • Iohexol Inj 300 MG/ML
  • Dextran 40
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Where

2 sites
Children's Hospital Colorado
Aurora, United States
Seattle Children's Hospital
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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