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A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

RecruitingPhase 2Ages 18 Years - anyAllMemorial Sloan Kettering Cancer Center
NCT05010031 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would still be effective to treat these tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically confirmed malignancy with at least one metastatic lesion referred for palliative radiotherapy * Pathogenic mutation in ATM (somatic and germline allowed) * ECOG performance status 0-2 * Age ≥ 18 years. * Able to provide informed consent. * Patients at reproductive potential must agree to practice an effective contraceptive method during radiation treatments. * Expected life expectancy of at least 6 months Exclusion Criteria: * Previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances. * Serious medical co-morbidities precluding radiotherapy. * Pregnant or breast-feeding women. * Lesions excluded from de-escalation include regions in which the risk of local disease progression is unacceptably high, including CNS disease and cord compression, and areas in which re-irradiation would not be feasible, including spinal cord overlap.
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What it tests

  • Palliative radiotherapy
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Where

7 sites
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, United States
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, United States
Memorial Sloan Kettering Commack (All protocol activities)
Commack, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, United States
Memorial Sloan Kettering Nassau (All protocol activities)
Uniondale, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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