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โ† Trials
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Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

RecruitingPhase 3Ages 18 Years - 90 YearsAllUniversity of Turin, Italy
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In plain words

What the trial is, and whether it could suit you

Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse following TI in adult critically ill patients. Patients with absolute indication or contraindication to vasopressor support will be excluded from this trial. Patients will be randomized 1:1 to a continuous infusion of noradrenaline started before induction titrated according to baseline mean arterial pressure. The primary outcome will be the incidence of cardiovascular collapse. Secondary outcomes will include lowest systolic blood pressure and cardiac arrest within 30 minutes from intubation.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient is admitted or scheduled for admission to a participating study hospital * Planned procedure is tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit * Critical illness (i.e. life-threatening condition with intubation required for cardiorespiratory failure or neurological impairment) * Administration of sedation (with or without neuromuscular blockade) is planned * Age 18 years or older Exclusion Criteria: * No vasopressors/inotropes at the moment of screening for eligibility * MAP \< 60 mmHg or \> 120 mmHg at the moment of screening for eligibility * Urgency of intubation precludes safe performance of study procedures * Intubation performed during cardiopulmonary resuscitation of a patient in cardiac arrest * Enrolled in another clinical trial that is unapproved for co-enrollment * Pregnant or suspected pregnancy
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What it tests

  • Noradrenaline
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Where

6 sites
CHU de Nantes
Nantes, France
Galway University Hospitals
Galway, Ireland
Humanitas Research Hospital
Rozzano, Italy
University Hospital San Luigi Gonzaga
Orbassano, Italy
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
Policlinico di Milano
Milan, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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