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NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT05017766 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel. It is to investigate antimicrobial resistance (AMR) including three clinical manifestations of infectious diseases: urinary tract infection, pneumonia and deep-seated infections. The focus is on four bacteria (E. coli, Klebsiella species, S. aureus, P. aeruginosa) that are part of the high priority list of World Health Organization (WHO). Residual patient samples are analysed for proteomic, metabolomic and transcriptomic analysis, immunocytochemical or fluorescence in-situ hybridisation (FISH) analysis, flow cytometry analysis (FACS) and immunophenotyping and exploration of bacterial properties.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with confirmed (i) urinary tract infection, (ii) pneumonia (including patients after lung transplantation, cystic fibrosis) or (iii) deep-seated infection with focus pathogen: * E. coli * Klebsiella species * S. aureus * P. aeruginosa * Controls: no detectable bacteria in routine microbiology lab and no other infection site at inclusion of the sample and follow up for 10 days, signed general consent * Clinical controls without obtained samples, but with confirmed (i) urinary tract infection, (ii) pneumonia (including patients after lung transplantation, cystic fibrosis) or (iii) deep-seated infection with focus pathogen: * E. coli * Klebsiella species * S. aureus * P. aeruginosa Exclusion Criteria: * Patients who have refused research and reuse of their data/samples (e.g. general consent) or any other decline (e.g. Patientenverfügung). * other than one of the focus bacteria in routine microbiology lab * Age: \<18 years * Controls without signed general consent
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What it tests

  • analysis of antimicrobial resistance
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Where

1 site
University Hospital Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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