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Transcriptional Map of Ovarian Cancer at the Single Cell Level

Recruitingn/aAges 18 Years - 80 YearsFemaleUniversity Hospital, Strasbourg, France
NCT05030805 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In 2020, epithelial ovarian cancer (EOC) accounts for 313,959 new cases and 207,252 deaths worldwide. The standardized 5-year net survival of a woman with EOC is 44% for cases diagnosed between 2005-2010. This is because 2 out of 3 cancers are found at an advanced stage with invasion beyond the ovaries to the entire peritoneum or distant metastasis. Treatment of EOC is currently based on platinum-based chemotherapy combined with paclitaxel and maximal cytoreduction surgery. Newer combination therapies may be introduced such as bevacizumab and oral poly ADP-ribose polymerase (PARP) inhibitors. Despite the combination of different therapeutic modes, the 5-year survival has not progressed much since the 1980s. The development of new and more effective therapies is essential but requires a better understanding of cancer heterogeneity and the identification of new therapeutic targets. Cancer

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women of legal age (≥ 18 years) * With an ovarian cancer confirmed by anatomopathological analysis * Operated in the gynecology department of the Strasbourg University Hospital between 2021 and 2024 * Patients having given their agreement to participate in the present trial and to the constitution of the collection of biological samples Exclusion criteria: * Chronic inflammatory disease (Lupus, rheumatoid arthritis, chronic inflammatory bowel disease, etc.) * History of immunotherapy treatment (anti PDL1...) * Previous appendixctomy for another reason * Impossibility to give the patient informed information (subject in an emergency situation, difficulties in understanding, language barrier, altered cognitive abilities) * Patient under legal protection or tutorship or curatorship. * Pregnant patient, breastfeeding * Persons deprived of liberty by judicial or administrative decision. * Persons under forced psychiatric care.
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What it tests

  • Not listed
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Where

1 site
Service Gynécologie Obstétrique, Hôpital de Hautepierre
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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