The Treatment of Bioartificial Liver With hiHep Cells After Extensive Hepatectomy

Inclusion Criteria: 1. Diagnosed as liver cancer, hepatolithiasis, benign liver tumor, with clear indications for liver resection; 2. Liver function Child A-B; 3. There is no contraindication to surgery for cardiopulmonary function; 4. The expected remaining liver volume/standard liver volume is less than 50%; Exclusion Criteria: 1. In the late stage of the disease, patients with frequent symptoms such as cerebral edema accompanied by cerebral herniation and clinical evidence indicating intracranial hemorrhage; 2. PaO2/FiO2 is less than 200 and cannot be corrected; 3. Patients with diffuse intravascular coagulation; 4. Those with active bleeding; 5. Uncontrolled infection; 6. The platelet count is less than 50,000/μL and cannot be corrected; 7. There is no blood vessel available for dialysis treatment; 8. HIV, HDV or HCV positive; 9. Drug abuse within 1 year; 10. Those with severe systemic circulatory failure; 11. Those who are highly allergic to the drugs used in the treatment process, such as plasma, heparin, protamine, etc.; 12. Combined pregnancy; 13. Patients with hepatorenal syndrome; 14. Patients with autoimmune liver disease; 15. Patients with non-alcoholic fatty liver and hereditary liver diseases (Wilson syndrome and a-antitrypsin deficiency); 16. Other conditions that the clinician believes cannot tolerate the treatment.