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"Fetal gRowth AbnorMality dEtection Trial"

RecruitingNAAges 18 Years - 45 YearsFemaleUniversity of Modena and Reggio Emilia
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In plain words

What the trial is, and whether it could suit you

The present trial intends to assess the diagnostic accuracy of symphysis fundal height (SFH) as opposed to SFH combined with point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC) in identifying small and large for gestational age infants (SGA and LGA infants) among low-risk pregnant women cared for by midwives after 35 weeks' gestation. Low risk pregnancies will be evaluated at 35-38, 40, 41, and 41+ weeks' gestation by midwives trained in SFH measurement and POC-US. Formal obstetric US performed by a perinatologist (i.e high risk obstetrician) will be performed in case SFH and/or POC-US suspect fetal growth or amniotic fluid abnormalities. Prenatal evaluations will be compared to actual birthweights.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Maternal age โ‰ฅ 18 years and ability to give informed consent. * Singleton gestation * Ultrasound examination that confirms or revises the EDD before 14 weeks of gestational age * Gestational age โ‰ฅ 35 weeks' gestation * Normal aneuploidy screening (1st trimester screening, 2nd trimester screening, integrated screening, NIPT) when performed * Spontaneously conceived pregnancy (i.e the current pregnancy is not the result of in vitro fertilization) Exclusion Criteria: * Fetal chromosomal or genetic abnormalities if invasive prenatal diagnosis is performed * Fetal malformations or soft markers identified on fetal anatomy survey * Episodes of uterine bleeding after 24 weeks gestation. Unobserved self-reported bleeding with confirmed intact pregnancy on ultrasound after the bleeding episode is not an exclusion criteria. * Uterine/placental abnormalities including uterine malformations (i.e bicornuate uterus, didelpus uterus), abnormal placentation (placenta previa, accreta, percreta), uterine fibroids. * Cerclage in the current pregnancy * History of intrauterine fetal demise * History of fetal growth restriction or birth weight \> 4Kg in a previous pregnancy * Fetal isoimmunization or alloimmunization * Fetal demise in previous pregnancies * Cancer (including melanoma but excluding other skin cancers). Dysplastic or pre-neoplatic conditions such as cervical intraepithelial neoplasia are admissible. * Endocrine disease including thyroid disease (recently diagnosed or whose medication dose is not stable), adrenal disease, diabetes mellitus (pregestational and gestational). * Renal disease with altered renal function (creatinine \> 0.9, proteinuria \> 300 mg/24 hour) * Epilepsy or other seizure disorder * Any collagen disease (lupus erythematosus, scleroderma, etc.) * Active liver disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes). Liver disorders accounting for cholestasis (including cholestasis of pregnancy) if diagnosed prior to enrollment. * Hematological disorder including alloimmune and isoimmune thrombocytopenia but excluding mild iron deficiency anemia (Hb \> 9 gm/dl). Patients with sickle cell disease are excluded. * Chronic pulmonary disease including asthma requiring regular use of medication and active TB. An asthma inhaler used on an as needed basis for a cold or an asthma attack is not considered regular use. * Heart disease except mitral value prolapse not requiring medication * Cardiovascular disorders: chronic hypertension, gestational hypertension or preeclampsia diagnosed prior to enrollment * Infectious diseases: HIV, CMV, toxoplasmosis, parvovirus B19, HBV, HCV * Chronic treatments with medications such as aspirin, steroids, anti-hypertensive agents, immunosuppressants, antineoplastic drugs. * Prior laparoscopic or open uterine surgeries where the uterine cavity was entered (such as myomectomies) * Resectoscopic myomectomies (prior resectoscopic polypectomies are not contraindications) * Prior classical cesarean deliveries.
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What it tests

  • Point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC)
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Where

3 sites
Azienda Ospedaliero Universitaria Policlinico di Modena
Modena, Italy
Cesena Hospital
Cesena, Italy
Foundation MBBM at San Gerardo Hospital, University of Milan-Bicocca School of Medicine and Surgery, Monza, Italy.
Monza, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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