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Catheter Ablation Versus Radio-Ablation for Ventricular Tachycardia: a Randomized Controlled Trial

RecruitingPhase 3Ages 55 Years - anyAllOttawa Heart Institute Research Corporation
NCT05047198 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

This study compares two arms - the current standard of care catheter ablation for Ventricular Tachycardia compared to stereotactic radiotherapy to non-invasively ablate ventricular tachycardia using a novel non-invasive ECG based body surface mapping technology. This allows investigators to identify ventricular tachycardia circuits to target for subsequent radio ablation. To summarize, the current standard of care invasive catheter ablation to the non-invasive radio ablation.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patient aged โ‰ฅ55 years of age 2. Cardiomyopathy (Left ventricular ejection fraction โ‰ค 35% and ICD in situ) AND 3. Recurrent VT events despite previous CA OR 4. VT events requiring intervention and PAINESD score โ‰ฅ 15 Exclusion Criteria: 1. Patients with NYHA Class IV heart failure \&/ or with LVAD in situ 2. Patients not expected to live for more than one year for any reason 3. Patients who have previously received thoracic radiotherapy 4. Patients who are enrolled in another randomized clinical trial 5. Patients who are unable or unwilling to provide informed consent 6. Patients aged โ‰ค54 years of age 7. Pregnancy (all women of child bearing age and potential will have a negative ฮฒ-HCG test before enrollment) 8. Breastfeeding 9. Women of childbearing age who refuse to use a highly effective and medically acceptable form of contraception (IUD, sterilization, birth control implant or birth control pill) throughout the study.
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What it tests

  • Control - Catheter Ablation for VT
  • Treatment - Non-Invasive Radio Ablation for VT
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Where

1 site
University of Ottawa Heart Institute
Ottawa, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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