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GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma

RecruitingNAAges 18 Years - 75 YearsAllChinese Academy of Sciences
NCT05047510 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma. The main purposes of this study include: ① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore. ② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients who have been diagnosed with hepatocellular carcinoma. 2. Planned to receive hepatectomy. 3. Liver function Child-Pugh A/B. 4. GPC-3 was validated highly expressed preoperatively. 5. Aged 18 to 75, and the expected lifetime is longer than 6 months. 6. Approved to sign the informed consent. Exclusion Criteria: 1. Allergic to IRDye800. 2. Enrolled in other trials in the past 3 months. 3. Another malignant tumor was found. 4. Undesirable function of heart, lung, kidney, or any other organs. 5. Unable to tolerate a hepatectomy. 6. The researchers considered inappropriate to be included.
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What it tests

  • Anti-GPC3-IRDye800CW
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Where

2 sites
Zhuhai People's Hospital
Zhuhai, China
The Affiliated Hospital of Southwest Medical University
Luzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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