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Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI

RecruitingPhase 2Ages 18 Years - 50 YearsAllHenry M. Jackson Foundation for the Advancement oโ€ฆ
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In plain words

What the trial is, and whether it could suit you

This study aims to assess the effect and safety of erenumab compared to placebo for the treatment of acute posttraumatic headache (PTH) in military service members and civilians with mild traumatic brain injury (mTBI).

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Male or female โ‰ฅ18 and โ‰ค50 years of age * mTBI from any cause including impact, rotational acceleration, blast, or a combination, has occurred within the prior 7 days * PTH has occurred within the prior 7 days * Able to provide informed consent * Likely to stay in the same geographical area for the duration of study * Has a personal health care provider for standard of care PTH and TBI, including education, diagnostic procedures including neuroimaging and treatment, as deemed clinically indicated by the health care provider Exclusion Criteria: * Sustained a moderate or severe TBI, rather than mTBI, indicated with at least 1 of the following associated with head injury: 1. abnormal structural imaging 2. loss of consciousness for \>30 minutes 3. alteration of consciousness/mental state for \>24 hours 3. post-traumatic amnesia for \>1 day * Participants with ongoing chronic migraine or other chronic daily headache disorders at the time of injury
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What it tests

  • Erenumab 140 Mg/mL Subcutaneous Solution
  • Placebo
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Where

4 sites
Womack Army Medical Center - Fort Liberty
Fort Bragg, United States
University of Pittsburgh Concussion Research Laboratory
Pittsburgh, United States
William Beaumont Army Medical Center
El Paso, United States
Madigan Army Medical Center
Tacoma, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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