Second-line Treatment of Primary Autoimmune Hemolytic Anemia

Inclusion Criteria: * Patients aged more than 18 years old from any sex with a diagnosis of primary warm autoimmune hemolytic anemia (AIHA) based on the presence of hemolytic anemia and serological evidence of anti-erythrocyte antibodies, detectable by the direct antiglobulin test who have disease progression or failure after treatment with steroid therapy, or who are intolerant to treatment, or who refuse standard treatment. * No evidence of a lymphoproliferative malignancy or other autoimmune-related underlying conditions. Exclusion Criteria: * any contraindications to the drugs of the study. * any identified secondary cause of the AIHA. * pregnant or lactating women.