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Glucose Homeostasis, Metabolomics and Pregnancy Outcomes After Bariatric Surgery

Recruitingn/aAges 18 Years - 45 YearsFemaleUniversitaire Ziekenhuizen KU Leuven
NCT05084339 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the GLORIA study is to determine whether an altered glucose metabolism (with more hypoglycaemia and glycaemic variability) and altered metabolomics during pregnancy after bariatric surgery contribute to the increased risk for adverse pregnancy outcomes such as small-for-gestational age infants. In addition, the investigators also aim to evaluate whether continuous glucose monitoring (CGM) can be used to diagnose gestational diabetes (GDM).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-45 years and with a singleton pregnancy with ultrasound-confirmed gestational age up to 11 weeks and 6 days * for the group with bariatric surgery: history of gastric bypass (RYBG) or sleeve gastrectomy (SG) * Participants need to speak and understand Flemish, French or English and have e-mail access. Exclusion Criteria: * multiple pregnancy * pregnancy ≥12 weeks * other types of bariatric surgery than RYBG or SG * known pregestational diabetes * a physical or psychological disease likely to interfere with the conduct of the study * medications known to interfere with glucose metabolism.
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What it tests

  • CGM
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Where

8 sites
OLV-Aalst-Asse
Aalst, Belgium
UZA
Antwerp, Belgium
ZNA Antwerpen
Antwerp, Belgium
Imelda Bonheiden
Bonheiden, Belgium
AZ St-Jan Brugge
Bruges, Belgium
UZ Gent
Ghent, Belgium
AZ Groeninge Kortrijk
Kortrijk, Belgium
UZ Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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