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FAST-IRM for HCC suRveillance in pAtients With High risK of Liver Cancer.

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

Intro: Hepatocellular carcinoma (HCC) is the 6th leading cause of cancer worldwide. In France, more than 10,000 new cases are identified each year. The latter occur in 85% of cases in cirrhosis, the most frequent causes of which are excessive alcohol consumption, metabolic syndrome or HBV/HCV infection. Patients with cirrhosis justify being included in monitoring programs involving the performance of a semi-annual liver ultrasound (US) in order to detect HCC eligible for curative treatment (liver resection or percutaneous ablation). This practice is considered to be cost-effective in the event of an annual incidence of HCC\> 1.5%. US in this context has a low sensitivity for the detection of HCC at the very early stage and the following observations have been made in the last 20 years: * The rate of patients detected at early stage BCLC 0 is around 30% by ultrasound * The rate of patien

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Patient enrolled in a screening program for at least 6 months in a tertiary hepatology center * Cirrhosis histologically proven or unequivocally suggested by non-invasive tests * Absence of HCC on imaging less than 3 months o * Liver parenchyma explorable by ultrasound * Child-Pugh A or B * Cirrhosis of non-viral or viral B/C cause controlled/healed * With an estimated annual risk of HCC\>3% * Written informed consent * Affiliation to a social security system Exclusion Criteria: * Child-Pugh C score * Active hepatitis B or C * Estimated annual risk of HCC\<3% * No prior enrollment in a screening program * Contraindication to Fast-MRI * Non-echogenic patient * Patient deprived of liberty * Patient under legal protection * Pregnant or breastfeeding woman * Patient on AME (state medical aid)
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What it tests

  • Liver ultrasound and fast-MRI
  • Liver ultrasound
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Where

1 site
Assistance Publique Hôpitaux de Paris - Hôpital Avicenne
Bondy, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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