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Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)

RecruitingPhase 4Ages 18 Years - 55 YearsFemaleMcMaster University
NCT05114096 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Pregnant people, aged 18 to 55 years old, at risk of preterm birth with a singleton or twins between 22 weeks and 0 days and \<34 weeks and 6 days gestation who have received only a single dose of Celestone within 24 hours 2. Capable of giving informed, written consent. Exclusion Criteria: 1. Contraindication to corticosteroids 2. Systemic corticosteroids for medical conditions during the pregnancy (e.g. lupus, severe asthma, Covid, etc). 3. Previous participation in this trial (in a previous pregnancy) 4. Known severe/life-threatening fetal or pregnant patient condition (e.g. fetal congenital/chromosomal abnormality) 5. Demise of one or more fetuses after 14 weeks and 0 days
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What it tests

  • Celestone + placebo
  • Celestone + Celestone
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Where

25 sites
University of Calgary, Cumming School of Medicine
Calgary, Canada
Alberta Health Services; University of Alberta
Edmonton, Canada
Royal Columbian Hospital
New Westminster, Canada
Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre
Surrey, Canada
University of British Columbia; BC Women's Hospital
Vancouver, Canada
Victoria General Hospital
Victoria, Canada
University of Manitoba, Health Sciences Centre
Winnipeg, Canada
University of Manitoba; St. Boniface General Hospital
Winnipeg, Canada

…and 17 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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