💬In plain words
What the trial is, and whether it could suit you
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D). However, given the 24h rhythmicity in substrate metabolism previously observed in healthy, lean men and the lack of such rhythmicity in men with insulin-resistance, the investigator hypothesize that appropriate timing of exercise training can maximize the metabolic health effects of exercise. Indeed, a preliminary study in humans revealed that afternoon high-intensity interval training (HIIT) exercise was more effective than morning exercise in improving 24h blood glucose levels in men with T2D. Another recent study in mice showed that the time of day is a critical factor in augmenting the beneficial effects of exercise on the skeletal muscle metabolome as well as on whole-body energy homeosta
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Pre-diabetes:
* Fasting plasma glucose: 6.1 to 6.9 mmol/L or
* 2-hour plasma glucose post 75g OGTT: 7.8 to 11.0 mmol/L and
* HbA1c: 6.0 to 6.4%
* or Insulin resistant: glucose clearance rate ≤ 360 ml/kg/min as determined using the Oral Glucose Insulin Sensitivity Index at Time 120 min.
* BMI \> 25 kg/m2
* To be willing and able to adhere to the specifications of the protocol;
* To have signed an informed consent document indicating that they understood the purpose of and procedures required for the study and were willing to participate in the study.
Exclusion Criteria:
* overt cardiovascular disease as assessed by medical history, physical exam, and abnormal ECG
* Treatment with any drug known to affect lipid or carbohydrate metabolism, except statins (to be stopped 3 weeks prior to study A), metformin or anti-hypertensive drugs (to be stopped 7 days prior to the studies);
* presence of liver or renal disease other than uncomplicated NASH or mild isolated proteinuria; uncontrolled thyroid disorder;
* Uncontrolled severe hypertension, systolic pressure ≥ 180 mm Hg or diastolic pressure ≥ 110 mm Hg;
* History of ischemic heart disease, tachyarrhythmia, QT interval prolongation, risk factors for torsade de pointes (eg hypokalemia), or taking any medication known to prolong the QT interval;
* History of serious gastrointestinal disorders (malabsorption, peptic ulcer, gastroesophageal reflux requiring surgery, etc.);
* Presence of a pacemaker;
* Having undergone a PET study or CT scan in the past year;
* Any contraindication to stopping statins for 3 months and stopping an anti-hypertensive medication and metformin for 7 days;
* smoking (\>1 cigarette/day) and/or consumption of \>2 alcoholic beverages per day;
* No blood donation two month prior the study;
* prior history or current fasting plasma cholesterol level \> 7 mmol/l or fasting TG \> 6 mmol/l.
💊
What it tests
- High-intensity interval training
Centre de recherche du CHUS
Sherbrooke, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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