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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

RecruitingPhase 1, Phase 2Ages 1 Year - anyAllModernaTX, Inc.
NCT05130437 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participated in Study mRNA-3927-P101. * Completed the EOT/ET visit in Study mRNA-3927-P101 and enroll in this study such that the first dose in this study is planned to be within 14±3 days of the last dose of mRNA-3927 in the mRNA-3927-P101 study. Exclusion Criteria: * Not expected to receive clinical benefit from continued mRNA-3927 administration, in the opinion of the Investigator. * Any clinical or laboratory abnormality or medical condition that, at the discretion of the Investigator, may put the individual at increased risk by participating in this study. * History of liver and/or kidney transplant.
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What it tests

  • mRNA-3927
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Where

22 sites
Ronald Reagan UCLA Medical Center
Los Angeles, United States
University of Stanford Medical Center
Palo Alto, United States
University of Michigan Hospitals
Ann Arbor, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Duke University Medical System (Duke Health)
Durham, United States
The Children's Hospital of Philadelphia (CHOP)
Philadelphia, United States
Texas Children's Hospital
Houston, United States
Hospital For Sick Children
Toronto, Canada

…and 14 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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