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A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia

RecruitingNAAges 19 Years - 80 YearsFemaleGangnam Severance Hospital
NCT05146778 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All of patients will undergo mastectomy with or without immediate breast reconstruction. Exclusion Criteria: * Previous history of breast surgery * Allergy to drug * Other cancer history * Underlying psychologic disorder * Patients with chronic pain requiring pain killers * Baseline SpO2 \<95% * Left ventricular EF \<40% * Bradycardia as HR \<50 bpm * BMI \>35kg/m2 * Pregnant woman
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What it tests

  • Opioid-free anesthesia
  • Conventional opioid-based anesthesia
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Where

1 site
Gangnam Severance Hospital
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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