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Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

RecruitingNAAges 18 Years - 75 YearsAllCHU de Reims
NCT05147649 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

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📋 Eligibility rules (as published)
Inclusion criteria : 1. OSAS patients * severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h * without CPAP treatment 2. Non-OSAS patients * absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : * \< 18 years old * \>75 years old * left-handed * BMI\> 40 kg/m² * another sleep disorder * central component of sleep apnea syndrome (central apnea index\> 5 / h) * current or past neurological pathology * respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) * MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) * taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), * uncorrected sensory impairment (vision or hearing) * protected by law. Exclusion criteria : * pregnant woman according to the positive beta-hCG test result * left-handed following the laterality questionnaire * MINI results showing: * a current mood episode * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) * an eating disorder * a diagnosis of bipolar disorder, current or past schizophrenia
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What it tests

  • functional magnetic resonance imaging
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Where

1 site
Chu Reims
Reims, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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