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Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

RecruitingNAAges 18 Years - 80 YearsAllUniversity of Texas Southwestern Medical Center
NCT05147909 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

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📋 Eligibility rules (as published)
Inclusion Criteria: The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise. Exclusion Criteria: 1. history of cardiopulmonary disease or chronic kidney disease, 2. treatment with antihypertensive medications, 3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness, (5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or \> 4.5 mg/dL.
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What it tests

  • Sodium Phosphate
  • Sodium Chloride
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Where

1 site
University of Texas Southwestern
Dallas, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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