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Study of the Ecological and Evolutionary Dynamics of Escherichia Coli in the Digestive Commensal Flora

Recruitingn/aAges 18 Years - 65 YearsAllAssistance Publique - Hôpitaux de Paris
NCT05153824 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Escherichia coli (E. coli) poses a major public health problem. E. coli is not only a commensal of the digestive tract but also a major opportunistic pathogen, first cause of urinary tract infections, first cause of bacteremia. However, little is known about the dynamics of intestinal colonization of the human host. Understanding the dynamics of colonization is crucial because selection for the major traits of E. coli is antibiotic resistance and virulence (the propensity to cause infection) works in commensalism, in the gut, not in infections. This study will make possible for the first time to study the colonization dynamics of E. coli in a large healthy host population. The main objective is to quantify the succession (gain, loss or replacement) of E. coli strains in the gut microbiota in healthy volunteers and how it depends on the properties of the host and the bacteria. This study

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📋 Eligibility rules (as published)
Inclusion Criteria: * healthy volunteer of both sexes between the ages of 18 and 65 years old included * subject considered healthy after a thorough general examination (interrogation, physical examination) * subject with normal transit with usually one molded saddle per day * BMI between 18.5 and 35 kg / m² included Exclusion Criteria: * Subject living in an institution * Known immunosuppression (HIV, concomitant immunosuppressive therapy, chemotherapy, long-term corticosteroids regardless of the dose\> 2 weeks in the last 6 months) * Chronic gastrointestinal illness (Chronic Hemorrhagic Recto-colitis, Crohn's Disease) * Any digestive resection except appendectomy and resection of polyps * Subject with a history (s) of bacteremia * Subject protected by law under guardianship or curator-ship * Pregnant or lactating woman * Subject deprived of liberty under judicial duress * Lack of affiliation to a social security scheme * Patient on State Medical Aid * Absence of signed consent before entering the study
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What it tests

  • Not listed
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Where

2 sites
Bichat Claude Bernard Hospital
Paris, France
Bichat Hospital, Clinical Investigation Center
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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