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Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

RecruitingNAAges 50 Years - 80 YearsAllUConn Health
NCT05174351 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100 * N=30 (Target: 30). * Age: 50 \~ 80 years. * ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction. * Chronic loop diuretic use * Currently on beta-blocker Exclusion Criteria: * Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease. * Heart rate \> 100 bpm * Recent hospitalization due to HF within 3 months * Non-English speaker
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What it tests

  • beta blocker discontinuation
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Where

1 site
UConn Health / John Dempsey Hospital
Farmington, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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