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Vitamin D to Improve Quadricep Muscle Strength

RecruitingPhase 2Ages 18 Years - 40 YearsAllChinese University of Hong Kong
NCT05174611 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury. Quadriceps muscle atrophy af

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Aged 18-40 with unilateral ACL injury 2. Sporting injury with a Tegner score of 7 3. Pre-op serum vitamin D level \<20 ng/ml 4. 4 months post-ACLR with serum Vitamin D level remained \<20ng/ml 5. LSI for quadriceps strength \<70% of contralateral leg at 4-month isokinetic assessment 6. Both knees without history of injury/prior surgery Exclusion Criteria: 1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively 2. Pre-operative radiographic signs of arthritis 3. Metal implants that would cause interference on MRI 4. Non-HS graft for ACLR 5. Patient non-compliant to the rehabilitation program 6. Regular sunbed users
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What it tests

  • Vitamin D3
  • Placebo
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Where

1 site
The Chinese University of Hong Kong
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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