AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

REducing SPEECH-related Side-effects of Deep Brain Stimulation in Parkinson's Disease Via Automated Speech Analysis

RecruitingNAAges 18 Years - anyAllInsel Gruppe AG, University Hospital Bern
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

The investigators' objective is to improve L-dopa sensitive PD-related dysarthria and at the same time reduce DBS-induced speech disorders with the help of automated acoustic analysis in patients with STN-DBS-induced dysarthria.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Idiopathic Parkinson-Syndrome according to the Movement Disorders Society Criteria * Treatment with bilateral deep brain stimulation in the subthalamic nucleus (for parts 1, 2 and 3) * Time since DBS-STN operation โ‰ฅ 3 month (for parts 1, 2 and 3) * Able to give informed consent as documented by signature * Fluent in Swiss-German or German * STN-DBS-induced dysarthria. In an operational definition, all PD-patients who reported -worsening of speech time-locked to STN-DBS implantation or patients with dysarthria on chronic stimulation improving with reduction of stimulation amplitudes in the context of postoperative routine follow up will be defined as having STN-DBS-induced dysarthria Exclusion Criteria: * Dysarthria caused in addition by a condition other than PD or DBS (e.g. stroke, myasthenia) * Clinical diagnosis of aphasia * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders and dementia. A Montreal Cognitive Assesment (MoCa) will be performed and patients with โ‰ค 20 of 30 points will be excluded * Change of parkinsonian medication in the last four weeks prior to inclusion in part 1 and 3 * Change of STN-DBS parameters in the last four weeks prior to inclusion (for parts 1 and 3) * Depression with acute suicidal ideation * Pregnant women
๐Ÿ’Š

What it tests

  • Change of stimulation amplitudes in dopaminergic OFF drug state
๐Ÿ“

Where

2 sites
Czech Technical University Prague
Prague, Czechia
University Hospital Inselspital, Berne
Bern, Switzerland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy