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Sleep and Circadian Mechanisms in Hypertension

RecruitingNAAges 25 Years - 64 YearsAllOregon Health and Science University
NCT05184933 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ages 25-64 * BMI 18.5-42kg/m2 * Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg) Exclusion Criteria: * Over 5 pack-years of smoking; * Prior shift work within 12 months prior to the study; * Travel greater than three time zones for at least 3 months; * History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction; * Acute or chronic diseases (except hypertension) that may affect outcome measures; * History of psychological conditions; * Sleep disorders, like severe sleep apnea, insomnia, etc.; * Prescription medications (Contraceptives and anti-hypertensive medications are permissible); * History of Illicit drug use and alcohol dependency; * 30 days free of cannabis use prior to the study; * Pregnancy; * Upper cut-off of 160/100 mmHg for BP
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What it tests

  • At-home Polysomnography
  • Circadian Protocol
  • Rested Wakefulness Trial
  • Overnight Sleep Trial
  • Regularized Sleep Schedule
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Where

1 site
Oregon Health and Science University
Portland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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