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Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients

RecruitingNAAges 18 Years - anyAllAcademisch Medisch Centrum - Universiteit van Ams…
NCT05188092 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of this study is to assess the effect of LUS-guided deresuscitation on duration of invasive ventilation in ICU patients. The investigators hypothesize that LUS-guided fluid deresuscitation is superior to routine fluid deresuscitation (not using LUS) with regard to duration of invasive ventilation. This study is an international multicenter randomized clinical trial (RCT) in invasively ventilated ICU patients.This study will include 1,000 consecutively admitted invasively ventilated adult ICU patients, who are expected not to be extubated within the next 24 hours a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Admission to one of the participating ICUs; * Invasively ventilated for less than 24 hours at randomization; * Expected to be under invasive ventilation for longer than 24 hours after randomization. Exclusion Criteria: * Age below 18 years old; * Suspected or confirmed pregnancy; * Participation in other interventional trials with similar endpoints; * Use of long term home mechanical ventilation; * Neurological condition that can prolong duration of mechanical ventilation (i.e.Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis); * Conditions in which LUS cannot be performed or correctly interpreted (i.e. chest wall abnormalities, morbid obesity, and pre-existing interstitial lung disease); * Conditions in which targeting a negative fluid balance is discouraged (i.e. subarachnoid bleeding, severe rhabdomyolysis (CK \> 20.000); * Previous participation in this RCT; * Patients transferred from another center and invasively ventilated for longer than 24 hours.
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What it tests

  • Lung ultrasound guided deresuscitation
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Where

3 sites
Rijnstate
Arnhem, Netherlands
Amsterdam UMC, location VUMC
Amsterdam, Netherlands
Amsterdam UMC, location AMC
Amsterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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