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Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE

RecruitingNAAges 19 Years - 90 YearsAllFirst Affiliated Hospital of Fujian Medical Unive…
NCT05188872 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Primary aldosteronism is the most common cause of secondary hypertension. The two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%). The gold standard that determines the diagnosis and treatment strategy of primary aldosteronism is adrenal vein sampling(AVS), but the success rate is only about 80%. Using CXCR4 as a probe for 68Ga-Pentixafor PET/CT imaging can guide the classification diagnosis and treatment strategy of primary aldosteronism, which is a favorable supplement to AVS. Superselective adrenal artery embolization(SAAE) and laparoscopy are the main operation treatments for primary aldosteronism. SAAE is an invasive interventional operation. It is a novel way to evaluate the changes in the structure and function of adrenal tissue pre-postoperative SAAE by using the changes in 68Ga-Pentixafor PET/CT imaging.

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📋 Eligibility rules (as published)
Inclusion Criteria: * adult population (aged 18 years or order); * patients with suspected or new diagnosed Primary aldosteronism (supporting evidence may include MRI, CT, laboratory tests); * patients who had scheduled 68Ga-BNU-PSMA PET/CT scan; * patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee; * healthy volunteers(aged 18 years or order). Exclusion Criteria: * patients with pregnancy; * the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.
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What it tests

  • 68Ga-Pentixafor
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Where

1 site
Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University
Fuzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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