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Visa-versa! Breaking Instead of Pushing the Pedals-C

RecruitingNAAges 18 Years - 80 YearsAllUniversity of Zurich
NCT05204693 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in huge training gain with a highly decreased oxygen demand and thus lower cardiovascular load. Pulmonary hypertension (PH) is a chronic condition associated with significant reduced exercise capacity and increased morbidity and mortality, resulting in reduced quality of life. Physical training has been shown to be beneficial in PH, even in severely limited patients. However, due to cardiopulmonary constraints in PH, training intensities may be very low, so that many patients are physically almost unable to perform exercise on a high enough level to maintain muscle mass. A low body muscle not only feeds the vicious cycle of decreasing exercise capacity, but also has ma

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📋 Eligibility rules (as published)
Inclusion Criteria: * In a stable condition on the same disease specific medication \>4 weeks. * Signed informed consent. * Patients with left-heart disease Exclusion Criteria: * Severe daytime hypoxemia (pO2 ≤7.3 kPa or \<55 mmHg). * Other clinically significant concomitant disease states (e.g., renal, hepatic dysfunction, etc.). * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorder, dementia or confusional state of the subject, neurological or orthopedic problems with inability to ride a bicycle. * Woman with known pregnancy (Women with known pregnancy will not be allowed into the study. It will however not be searched for early unknown pregnancy in woman of child-bearing potential, as cycling is not contraindicated in early unknown pregnancy stage and we thus do not plan routine pregnancy tests before study entrance in women of childbearing potential). * Enrolment into another clinical trial with active treatment.
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What it tests

  • 15 minutes eccentric cycling
  • 15 minutes concentric (normal) cycling
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Where

1 site
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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