💬In plain words
What the trial is, and whether it could suit you
This study through to the pregnant woman blood concentrations of dexamethasone therapy after research, explore the pharmacokinetic data of dexamethasone in pregnant women, Chinese pregnant women dexamethasone pharmacokinetic model, provide a reference for the clinical use of dexamethasone dose, through the biomarkers of dexamethasone to promote fetal lung maturity and other metabolomics, It provides the basis for the effectiveness and safety study of dexamethasone.
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Aged 20-40 (inclusive);
* Body mass Index (BMI) 18.5-27.9kg /m2 (inclusive)
* Single and twin pregnancy;
* Premature delivery at 24-36 weeks;
* No antibiotics, prebiotics or probiotics were used one month before feces collection (such as Bifidobacterium triplex live powder, Lactobacillus acidophilus tablet, compound Lactobacillus acidophilus tablet, Bacillus subtilis diplex live intestinal capsule, etc.);
* Preeclampsia patients accounted for about 1/10 of each group;
* Use dexamethasone I.M. 5mg Q12h regimen (or other dexamethasone administration regimen) to promote fetal lung maturation.
Exclusion Criteria:
* Ectopic pregnancy;
* Suffering from diabetes, fetal distress, serious infectious diseases (such as sepsis, septic shock), fever;
* Those who have taken glucocorticoid drugs within 2 weeks before joining the clinical trial;
* Those who took clindamycin during the study period;
* Congenital fetal malformation or fetal hypoxia in early pregnancy;
* Convulsive patients;
* HIV/HCV/ HEPATITIS A, drug abuse history;
* Suffering from chorioamnitis, endometritis;
* Placental abruption, severe intrauterine bleeding;
* Pregnant women whose cervical dilation is greater than or equal to 4 cm or whose cervical length is less than or equal to 20 mm by ultrasound examination;
* Pregnant women who took food or drugs during the study that might affect the safety of the fetus;
* Pregnant women participating in other clinical trials.
Dongyang Liu
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
HealthTeky