🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Reconstruction in Extended MArgin Cancer Surgery

Recruitingn/aAges 18 Years - anyAllUniversity Hospital Southampton NHS Foundation Tr…
NCT05219058 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Advanced pelvic cancers are uncommon, with treatment being challenging. Around 4000 patients every year need treatment in the UK. Cancers can involve multiple organs and often need radiotherapy and chemotherapy before surgery. Surgery usually requires removal of multiple pelvic organs, including muscles, bone, and skin around the anus (the perineum). This can lead to complications relating to both the empty pelvis syndrome and closure of the perineal defect. Reconstruction is challenging, with frequently occurring complications, reducing speed of recovery and quality of life. This study investigates complication frequency, quality of life and expenses following different reconstruction techniques. The investigators hope to improve patient and doctor decision-making in this area and find the best methods of reconstruction to improve outcomes. REMACS has three work packages: 1. Maintena

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female patients aged 18 or older * Patients that have undergone pelvic exenteration or abdominoperineal excision at participating sites, at any time, that have complete data (work package 1 - Colorectal Surgery Database) * Patients undergoing pelvic exenteration or abdominoperineal excision at participating sites (work package 2 - prospective study) * Patients that have already had pelvic exenteration or abdominoperineal resection that can speak English (work package 3 - mixed-methods study) Exclusion Criteria: * Patients eligible for, but that are unfit, decline or are not offered abdominoperineal excision or pelvic exenteration surgery * Patients that undergo surgery by an intersphincteric abdominoperineal resection approach * Patients that are unable to complete the questionnaire over the telephone or online with a researcher * Patients unable or unwilling to provide informed consent * Patients that are prisoners in the custody of HM Prison Service or who are offenders supervised by the probation service
💊

What it tests

  • Biological mesh reconstruction
  • Myocutaneous flap reconstruction
  • Primary closure reconstruction
📍

Where

18 sites
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
Salisbury NHS Foundation Trust
Salisbury, United Kingdom
Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
University Hospitals Sussex NHS Foundation Trust
Brighton, United Kingdom
Royal Devon University Healthcare NHS Foundation Trust
Cornwell, United Kingdom
Dorset County Hospital NHS Foundation Trust
Dorchester, United Kingdom
NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom

…and 10 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy