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โ† Trials
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TERPS Trial for de Novo Oligometastic Prostate Cancer

RecruitingPhase 2Ages 18 Years - anyMaleUniversity of Maryland, Baltimore
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In plain words

What the trial is, and whether it could suit you

This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patient must have at least one and up to three asymptomatic metastatic tumor(s) of the bone or soft tissue (with at least one bone metastasis) develop within the past 6-months that are seen on imaging. Up to five lesions are allowed on advanced functional imaging such as fluciclovine (Axumin), choline or PSMA PET-CT scan. 1. CT or MRI scan within 6 months of enrollment 2. Bone scan within 6 months of enrollment 3. Fluciclovine (Axumin), choline, or PSMA PET-CT scan within 6 months of enrollment (PET-CT scan is reasonable for study entry imaging as an alternative to CT/MRI scan and bone scan) 2. Histologic confirmation of malignancy (primary or metastatic tumor). 3. Patient may have had prior systemic therapy and/or ADT associated with treatment within 9-months of enrollment. 4. PSA \> 0.5 but \<100. 5. Patient must be โ‰ฅ 18 years of age. 6. Patient must have a life expectancy โ‰ฅ 12 months. 7. Patient must have an ECOG performance status โ‰ค 2. 8. Patient must have the ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: 1. Castration-resistant prostate cancer (CRPC). 2. Prior radiation therapy to an overlapping site of a target lesion that would preclude further radiation therapy 3. Spinal cord compression or impending spinal cord compression. 4. Suspected pulmonary and/or liver metastases (greater \>10 mm in largest axis). 5. Patient receiving any other investigational agents. 6. Inability to receive any form of systemic therapy in the opinion of a treating medical oncologist . 7. Unable to lie flat during or tolerate PET/MRI, PET/CT or SABR. 8. No radiographical evidence of cranial metastasis. 9. Refusal to sign informed consent.
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What it tests

  • Prostate radiation (XRT)
  • Systemic Therapy
  • Stereotactic ablative radiation therapy (SABR)
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Where

10 sites
UC San Diego Moores Cancer Center
La Jolla, United States
KU Medical Center- Cancer Center
Kansas City, United States
Maryland Proton Treatment Center
Baltimore, United States
UMMC
Baltimore, United States
Upper Chesapeake Health
Bel Air, United States
Central Maryland Radiation Oncology
Columbia, United States
Baltimore Washington Medical Center
Glen Burnie, United States
Sidney Kimmel Cancer Center at Jefferson Health
Philadelphia, United States

โ€ฆand 2 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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