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Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU

Recruitingn/aAges 18 Years - anyAllCopenhagen University Hospital, Hvidovre
NCT05225402 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand. Norepinephrine (NE) is recommended as first choice vasoactive agent for the treatment of septic shock. However, the dynamic effects of NE on macro- and microcirculation and perfusion parameters has not been described in detail in the context of septic shock, precluding rational individualized titration of NE and fluids, as recommended recently. In the present prospective observational multicenter study in adult septic shock patients, we intend to explore the effects of NE on preload dependency and tissue perfusion by evaluating the correlation and potential discrepancies between macro- and microcirculation both during titration of NE and after fluid resuscitation. The conclusions drawn from our

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📋 Eligibility rules (as published)
Inclusion Criteria: * Suspected or documented infection * Need for vasopressors to maintain mean arterial blood pressure (MAP) ≥65 mmHg * Serum lactate levels \>2 mmol/L * Norepinephrine infusion of \> 0.2 mcg/kg/min Exclusion Criteria: * Absolute contraindication for esophageal doppler or urinary catheter insertion as noted in the patients' charts. * Severe valvular pathology and cardiac arrhythmias resulting in severe hemodynamic instability. * Lithium treatment * Treatment with other vasopressor or inotropic drugs.
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What it tests

  • Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
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Where

1 site
Hvidovre Hospital
Hvidovre, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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