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Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire de Nice
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Invasive mechanical ventilation for more than 48 hours 2. Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria: 1. SpO2\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O 2. Cough effectiveness on tracheal aspirations 3. Lack of hemodynamic instability and of disorders of consciousness 3. Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria: 1. Obesity, defined by a body mass index\> 30 kg/m² 2. Chronic obstructive pulmonary disease 3. Chronic heart disease Exclusion Criteria: 1. Age \<18 years and pregnant women 2. Patients with a decision of not to resuscitate 3. Poor echogenicity 4. Severe mitral valve disease (leakage and/or stenosis, bioprosthesis) 5. Patients with pacemaker 6. Tracheostomy 7. Chronic neuromuscular or neurodegenerative diseases
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What it tests

  • Spontaneous breathing trial
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Where

3 sites
CHU de Dijon
Dijon, France
CHU de NICE
Nice, France
Hôpital Cochin
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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