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Stress Phenotypes and Preterm Birth

RecruitingNAAges 18 Years - anyFemaleColumbia University
NCT05229666 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Pregnant women 18 years of age or older (based on self-report) * Not currently smoking, drinking alcohol, or taking drugs (based on self-report) * Planning to deliver at CUIMC/NYP (based on self-report) * In the first or second trimester of pregnancy (prior to 28 weeks gestation) (based on self-report of estimated date of delivery) Exclusion Criteria * Multi-fetal pregnancy (based on self-report) * Taking medications regularly that affect the cardiovascular and inflammatory systems, including NSAIDS and other anti-inflammatories, ฮฑ blockers, ฮฒ blockers, corticosteroids, chronic-use asthma medications (e.g. beta2- adrenoceptor agonists) (based on self-report) * This does NOT include baby aspirin or low-dose aspirin, as baby aspirin / low-dose aspirin is not normally considered to be an NSAID. * Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis (based on self-report)
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What it tests

  • Cognitive Challenge
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Where

1 site
Columbia University Irving Medical Center
New York, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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