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Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease

Recruitingn/aAges 18 Years - anyAllXuanwu Hospital, Beijing
NCT05232240 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension. Ambulatory 24-hour blood pressure monitoring (ABPM) will be performed at baseline and one year after the enrollment. The primary purpose of the study is to delineate the relationship of blood pressure variability (BPV) with the risk of composite vascular events in non-hypertensive patients with ICVD. The factors related to BPV, as well as the potential modulators of the associations between BPV and vascular risk, will be further explored among these patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging. 2. Less than 90 days after onset of ischemic stroke or TIA symptoms. 3. The blood pressure measured 5\~90 days after the ICVD onset without any anti-hypertension treatment is less than 140/90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement). 4. Consent to participate in the study. Exclusion Criteria: 1. A definite diagnosis of hypertension. 2. Under anti-hypertension treatment. 3. Worsening neurological conditions. 4. With a National Institute of Health Stroke Scale score more than 5 points. 5. Intracranial hemorrhage. 6. Autonomic failure. 7. With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years. 8. With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline. 9. Mental disease. 10. Pregnant.
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What it tests

  • blood pressure variability measured by ambulatory 24-hour blood pressure monitoring
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Where

1 site
Xuanwu Hospital, Capital Medical University
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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