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The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)

Recruitingn/aAges 18 Years - 80 YearsAllFederal State Budgetary Institution, V. A. Almazo…
NCT05242393 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients. It is designed as an observational cohort study with the retrospective and prospective longitudinal arms.

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📋 Eligibility rules (as published)
Inclusion Criteria: * acute (symptom onset to admission \<1 days) ischemic stroke * ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery * age 18-80 years * moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS\>=5) * intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable) * informed consent Exclusion Criteria: * secondary parenchymal hemorrhage (\>hemorrhage index -2) * clinically unstable or life-threatening conditions * known progressive neurological diseases * known psychiatric diseases * concomitant benzodiazepine medication * drug or alcohol abuse * pregnancy * disability to participate in the study * congestive heart failure with reduced ejection fraction (\<=45%) or New York Heart Association (NYHA) classification III-IV functional class
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What it tests

  • No intervention is planned
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Where

1 site
Almazov National Medical Research Centre
Saint Petersburg, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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