Radiation Cystitis Treated With Pentosan Polysulfate Sodium Trial

Inclusion Criteria: 1. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and in the study protocol. 2. Patients must be ≥20 years of age 3. Patients must have received definitive radiation therapy for cancer in pelvic area. 4. Time from the end of radiation therapy to radiation cystitis must be longer than 6 months. 5. Radiation cystitis with lower urinary tract symptoms or hematuria. Exclusion Criteria: 1. Abnormal liver function with indication of AST, ALT, or total bilirubin ≥ 1.5 times higher than normal 2. Abnormal renal function with serum creatinine ≥ 1.5 times higher than normal 3. Abnormal coagulation profile with PT/INR higher than normal 4. Thrombocytopenia with platelet counts \< 100,000/μL 5. Pregnant or breastfeeding, expecting to pregnancy, or positive for pregnancy test 6. Patients who have systemic inflammatory symptoms during screening period (ie, fever up to 38℃ or WBC counts \>12,000/μL) 7. Patients with known urinary tract infection within 6 months of randomization. 8. Any previous intravesical instillation within 6 months of randomization (ie, hyaluronic acid instillation) 9. Any previous hyperbaric oxygen therapy within 6 months of randomization 10. Any previous treatment with pentosan polysulfate sodium within 6 months of randomization 11. Has history of thrombocytopenia, hemophilia or bladder cancer 12. Has known history of Human Immunodeficiency Virus (HIV) or organ transplantation 13. Has known history of drug allergy to pentosan polysulfate sodium 14. Has hematuria caused by clinically active urolithiasis or urothelial carcinoma