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TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Heart Failure

Recruitingn/aAges 18 Years - anyAllJohn Paul II Hospital, Krakow
NCT05250349 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

TRACE-IMPAIR is a prospective, clinical study of consecutive patients that evaluates the relationship between heart failure (HF) and cognitive impairment in relation to carotid and cerebral flow. The carotid and cerebral flow will be assessed using Doppler ultrasonography, and cognitive function will be estimated during routine neuropsychological tests. It is an observational, three(natural)-group, single-center study. It is also an Academic Registry - the scientific activity of the Faculty of Medicine, Collegium Medicum, Jagiellonian University, and John Paul II Hospital.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinically stable patients (NYHA I-III symptoms) with HF (for at least 6 months) either of ischemic or inflammatory etiology as well as genetic cardiomyopathies * Signed informed consent form * Consent to imaging studies: echocardiography, carotid and transcranial Doppler sonography and neuropsychological tests (MMSE and MoCA). Exclusion Criteria: * Co-existing, severe, irreversible disease (e.g. advanced cancer) * Previously diagnosed dementia (including severe dementia - MMSE and MoCA score \<10) * Psychiatric condition which may influence cognitive function * Acute, decompensated HF * Reversible cause of HF - tachyarrhytmic, peripartum or toxic cardiomyopathy, acute myocarditis, acute myocardial infarction * Aortic stenosis * Cerebral stroke in the preceding 3 months * Lack of transcranial Doppler acoustic window * Echocardiographic projections precluding adequate measurements * Anemia with Hemoglobin \< 8 g/dl * Alcohol or psychoactive agents abuse
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What it tests

  • Echocardiography
  • Doppler sonography
  • Neuropsychological tests
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Where

1 site
Department of Cardiac and Vascular Diseases, The John Paul II Hospital
Krakow, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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