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The Cardiovascular Impact of Hot Flushes

Recruitingn/aAges 40 Years - 70 YearsFemaleUniversity of Minnesota
NCT05251324 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asymptomatic women. Aim 2: To determine if heat-induced hot flushes in symptomatic women will cause reproducible cardiovascular and respiratory responses. The investigators hypothesize that heat-induced hot flushes produce similar and reproducible cardiovascular and respiratory responses to spontaneous hot flushes. Aim 3: To determine if body fat percentage influences hot flush severity or frequency duri

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📋 Eligibility rules (as published)
Inclusion Criteria: * Postmenopausal (may have or may not have hot flushes) * Have not started hormone therapy and/or will discontinue hormone therapy for the duration of the study Exclusion Criteria: * Reported nicotine/tobacco use within the last six months * Diabetic or asthmatic * Diagnosed significant carotid stenosis * History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury * Existing metabolic or endocrine abnormalities * Use of heart/blood pressure medications that are determined to interfere with study outcomes * Unwilling to discontinue use of OC (or other hormonal contraceptives, including intrauterine devices or contraceptive implants) and/or MHT * Pregnant or breastfeeding * Unwilling or unable to refrain from consuming caffeine or alcohol in the 12 hours before visit two or three * Unwilling or unable to refrain from vigorous exercise (at least 10 minutes in duration) in the 12 hours before visit two or three * Unwilling or unable to fast in the eight hours before visit two or three * Body mass index greater than or equal to 35 kg/m\^3
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What it tests

  • Hot Flush Induction
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Where

1 site
University of Minnesota
Minneapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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