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His-Bundle Corrective Pacing in Heart Failure

RecruitingNAAges 18 Years - anyAllUniversity of Rochester
NCT05265520 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older (no upper age limit) * Optimal medical therapy for heart failure by current guidelines * Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following: * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb) Exclusion Criteria: * Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization * Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology * Unable or unwilling to follow study protocol * Less than 12 months life expectancy at consent * Pregnancy or planned pregnancy during duration of the study * On heart transplant list or likely to undergo heart transplant
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What it tests

  • His-CRT implantation
  • BIV-CRT implantation
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Where

14 sites
University of Arizona
Phoenix, United States
Cedars-Sinai Medical Center
Los Angeles, United States
University of South Florida
Tampa, United States
Northwestern Memorial Hospital
Chicago, United States
Rush University Medical Center
Chicago, United States
University of Chicago
Chicago, United States
Valley Health System
Ridgewood, United States
Weill Cornell Medical College
New York, United States

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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