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Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.

Recruitingn/aAges 18 Years - anyAllOdense University Hospital
NCT05266092 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year). Cardiovascular complications and bloodstream infections (BSIs) account for the vast majority of deaths in HD patients. In Denmark, BSIs occur in 14% of HD patients per year and is most frequently caused by Staphylococcus aureus (44%). The most frequent infectious complication is endocarditis that has fatal outcomes in ≈50% of the cases. Overall, 10% of HD patients die within 30 days after a positive blood culture for S. aureus. This project aims to answer key questions regarding HD patients' decreased ability to fight S. aureus BSIs and in particular the potential exacerbating effect of HD. We hypothesize that HD patients' blood is significantly compromised by the process

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📋 Eligibility rules (as published)
Participants with chronic kidney disease undergoing hemodialysis Inclusion criteria * Age \>18 years * Chronic kidney disease * Hemodialysis Exclusion criteria: \- Acute kidney disease Participants with chronic kidney disease, not in dialysis Inclusion criteria * Age \>18 years * Chronic kidney disease (eGFR from \<15 to 44) Exclusion criteria: * Acute kidney disease * Hemodialysis * Peritoneal dialysis Participants with chronic kidney disease undergoing peritoneal dialysis Inclusion criteria * Age \>18 years * Chronic kidney disease * Peritoneal dialysis Exclusion criteria: \- Acute kidney disease Healthy volunteers Inclusion criteria * Age \>18 years * Blooddonors Exclusion criteria: \- NA
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What it tests

  • Observational study
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Where

1 site
Odense University Hospital
Odense, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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