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Reperfusion Injury After Endovascular Stroke Treatment

Recruitingn/aAges 18 Years - anyAllMedical University of Graz
NCT05273216 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO). The most serious MT-related complication is secondary intracranial hemorrhage (ICH) occurring in 20-25%. Post- recanalization hyperperfusion might be an important risk factor/mechanism of MT-related ICH. In pilot studies, bedside transcranial Duplex sonography (TCD) was identified as a promising screening tool for cerebral hyperperfusion predicting ICH - the hallmark feature of reperfusion injury. There is an unmet need to identify risk factors for ICH after MT as it relates to poor prognosis, no proven treatment is available, and it delays/prohibits usage of anticoagulants/-thrombotics necessary for preventing recurrent stroke. Main objectives: To explore the range and clinical impact of hemodynamic changes after MT as detected on bedside TCD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * stroke due to large vessel occlusion of the anterior cerebral circulation (internal carotid artery, middle cerebral artery) receiving mechanical thrombectomy. Exclusion Criteria: * basilar artery occlusion * age below 18 years
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What it tests

  • Transcranial Duplex Sonography
  • Brain MRI
  • Blood biomarkers
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Where

3 sites
Medical Univerity of Graz, Department of Neurology
Graz, Austria
Medical University of Innsbruck, Department of Neurology
Innsbruck, Austria
Paracelsus Medical University, Department of Neurology
Salzburg, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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