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A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllAllist Pharmaceuticals, Inc.
NCT05276726 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Evaluate the safety and tolerability, drug levels, and clinical activity of JAB-21822 in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors with KRAS p.G12C mutation and a serine/threonine kinase 11 (STK11) co-mutation.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Pathologically documented, locally-advanced or metastatic NSCLC with KRAS p.G12C mutation identified through molecular testing. 2. STK11 co-mutation and KEAP1 Wild-Type (local confirmation) 3. Treatment naïve or have received at least 1 prior standard therapy for advanced NSCLC 4. ECOG 0-1 Exclusion Criteria: 1. Has CNS metastases or carcinomatous meningitis, except treated CNS metastases with no evidence of radiographic progression or hemorrhage for at least 28 days 2. Any severe and/or uncontrolled medical conditions 3. Active infection requiring systemic treatment within 7 days 4. Therapeutic radiation therapy within 3 weeks of study day 1
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What it tests

  • JAB 21822
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Where

21 sites
Research site08
Beijing, China
Research site09
Beijing, China
Research site021
Beijing, China
Research site02
Beijing, China
Research site01
Beijing, China
Research site013
Beijing, China
Research site010
Chongqing, China
Research site05
Xiamen, China

…and 13 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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