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Exploring the Role of Neuroactive Steroids in Tourette Syndrome

RecruitingNAAges 8 Years - 12 YearsAllUniversity of Utah
NCT05281445 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by motor and phonic tics. The studies proposed in this application will explore the endocrine mechanisms underlying two of the least well-understood biological characteristics of TS, namely its marked male predominance and stress susceptibility. In particular, our exploratory studies will characterize the steroid profile in TS-affected boys and girls to identify novel potential biomarkers and therapeutic targets for this disorder.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnostic criteria of TS for cases (and lack of any tic disorders for controls) * Age between 8 and 12 years old (this age range is to ensure that TS participants can perform the tic suppression task) * confirmation of sexual development by parent and/or self-reported Tanner stage of pubic hair development. Exclusion Criteria: * major psychiatric disorders such as a psychotic disorder, autism spectrum disorder, conduct disorder, and substance use disorder; * other neurological disorders; * clinically significant endocrinological disorders; * use of therapies that can modify hormonal profile; * pharmacotherapies that may change stress sensitivity, such as antidepressants and anxiolytics.
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What it tests

  • Tic suppression task
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Where

1 site
University of Utah
Salt Lake City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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