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Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease

RecruitingNAAges 18 Years - anyAllOdense University Hospital
NCT05283512 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The use of contrast media (CM) poses a risk of post-contrast acute kidney injury (PC-AKI), especially among patients chronic kidney disease (CKD). International guidelines recommend intravenous (IV) hydration with isotonic 0.9% NaCl for three-four hours pre-contrast and four-six hours post-contrast. Recent studies have proven that oral hydration or no hydration is non-inferior to IV hydration in patients with mild to moderate CKD (eGFR 30-60 mL/min/1.73 m2). However, no randomized controlled trials have evaluated alternative hydration methods against the guideline-recommended hydration protocol for the prevention of PC-AKI in high-risk patients with severe CKD (eGFR \< 30 mL/min/1.73 m2). Thus, the main focus of this trial is to evaluate IV hydration vs. oral hydration for their efficacy to prevent of PC-AKI in patients with severe CKD, who are scheduled for an elective contrast-enhance

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📋 Eligibility rules (as published)
Inclusion Criteria: * eGFR \< 30 mL/min/1.73 m2 * Scheduled for elective IV CECT * Age ≥ 18 * Signed informed consent Exclusion Criteria: * Allergy to Iodine * Pregnancy * Active dialysis treatment * Acute infectious or inflammatory disease * Acute pre- and/or post-renal kidney failure * Unable to understand study information
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What it tests

  • Preventive treatment with IV-hydration
  • Preventive treatment with oral hydration
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Where

1 site
Department of Cardiology
Odense C, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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