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โ† Trials
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Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Recruitingn/aAges 2 Years - 99 YearsAllArkansas Children's Hospital Research Institute
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In plain words

What the trial is, and whether it could suit you

this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Individuals who are diagnosed with Primary Ciliary Dyskinesia OR * Individuals with abnormal PCD diagnostics (abnormal ciliary biopsy or PCD genetics) OR * Individuals with unexplained bronchiectasis OR * Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following): * Neonatal respiratory distress * Organ laterality defects * Year-round cough starting in first year of life or bronchiectasis on chest CT * Year-round nasal congestion starting in first year of life or pansinusitis * Multiple ear infections in the first two years of life with sequelae (e.g. ear tubes, chronic effusion, abnormal audiological exam) * History of recurrent pneumonias (at least 2 in one year or more than 3 at any time) * Ability to provide consent for participation in study by the participants or guardian * Ability to perform the test * Age \>= 2 years of age Exclusion Criteria: * Individuals who are unable to understand the requirements of the study. * Individuals (or guardians) who are unwilling to provide consent. * Individuals who are unable to complete the testing * Recent history of sinus surgery (within four weeks) or bloody nose (within one week) of testing (they can be included at a later date) * Patients who are currently being treated (within one week) with antibiotics for sinusitis or respiratory symptoms (they can be included at a later date) * Age \<2 years of age
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What it tests

  • Not listed
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Where

1 site
Arkansas Children's Hospital
Little Rock, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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