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Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study

RecruitingNAAges 18 Years - 50 YearsFemaleSamuel Lunenfeld Research Institute, Mount Sinai …
NCT05290129 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect. Oxytocin is a drug that is routinely used to help the uterus to contract and keep it contracted after delivery. Consequently, it will help to reduce blood loss after delivery. In order to determine the minimal effective dose, the investigators will conduct a dose-finding study. The first patient will receive a set oxytocin infusion. The next patient's infusion dose of oxytocin, will either increase or decrease, depending on how the previous patient responds in terms of uterine tone. If the response is satisfactory with the infusion dose used, the next patient will either receive the same infusion dose or it will be decreased depending on a probability of 1:9. If the response is not satisfactory, then the infusion dose

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📋 Eligibility rules (as published)
Inclusion Criteria: • All patients with induced or augmented labour undergoing cesarean delivery under neuraxial anesthesia (at least 3 hours of prior exposure to oxytocin during labour) Exclusion Criteria: * All patients who refuse to give written informed consent * All patients who declare allergy or hypersensitivity to oxytocin * A history of hypertension and/or severe cardiac disease(s) * All patients who have contraindications for neuraxial anesthesia * All patients who will be converted to general anesthesia intraoperatively * All patients with placenta previa and multiple gestation
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What it tests

  • Oxytocin
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Where

1 site
Mount Sinai Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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