Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma

Inclusion criteria: 1. Patients age 18-89 admitted with a lower extremity or pelvis fracture requiring surgical stabilization 2. Acute blood loss anemia as defined by hemoglobin concentration between 7.0-11.0g/dL within seven days post-operatively from definitive fracture stabilization during the hospital admission Exclusion criteria: 1. History of intolerance or hypersensitivity to IV iron supplementation 2. Active hemorrhage requiring greater than two units (whole blood or pRBCs) transfused perioperatively 3. 1\. Multiple planned operative procedures during the trauma admission, excluding orthopaedic staged procedures for the fracture meeting inclusion criterion one (such as temporizing external fixator application and washout for open fracture) in which subjects otherwise meet qualifications for enrollment after definitive stabilization 4. Pre-existing hematologic or coagulation disorder (e.g., thalassemia, sickle cell disease, hemophilia, von Willibrand's disease, or myeloproliferative disease) 5. Diagnosis of chronic kidney disease and/or chronic liver disease 6. Known infection, inflammatory condition (e.g., systemic lupus erythematosus, rheumatoid arthritis, and ankylosing spondylitis), or malignancy 7. Pregnancy 8. Iron overload (defined as serum ferritin concentration ≥ 1,000ng/mL, serum iron concentration \> 160μg/ dL, or serum transferrin saturation ≥ 50%) or any condition associated with iron overload (e.g., hemochromatosis and aceruloplasminemia) 9. Patients that are tenets of the Jehovah's Witness faith 10. Vulnerable populations including pediatric patients, geriatric populations 90 or older, incarcerated individuals, those unable to provide informed consent 11. Inability to refrain from oral iron supplementation during study period 12. Current or recent (within 30 days) use of immunosuppressive agents 13. Use of any intravenous iron therapy or recombinant human erythropoietin formulation within the previous 30 days